105'5 Spreeradio offers a variety of programs including "Jochen Trus am Morgen" and "Das Wohlfühl-Wochenende." Listeners can engage with "Song-Duell" to vote for daily songs and find "Verbrauchertipps" and "Film- & Serientipps." The station also features "Reportagen" on various topics and supports local initiatives like "Berliner Vereine."